Preliminary study on lumbar facet joint derived inflammatory factors in degenerative lumbar spinal canal stenosis
- VernacularTitle:退变性腰椎管狭窄中小关节源性炎性因子作用的初步探讨
- Author:
Hai CHEN
;
Kai GONG
;
Zhuojing LUO
- Publication Type:Journal Article
- Keywords:
degenerative lumbar spinal canal stenosis,interleukin-1?,tumor necrosis factor-?
- From:
Orthopedic Journal of China
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To initially approach the role of lumbar facet joint derived inflammatory factors in degenerative lumbar spinal canal stenosis. [Methods]Totally 75 cases of degenerative lumbar spinal canal stenosis(LSCS)(n=41)and lumbar intervertebral disc herniation(LDH)(n=34) undergoing posterior lumbar spinal surgery in our department were evaluated in terms of the extent of degenerative arthrosis according to the Weishaup grading criteria.The grading of backleg pain,melosalgia and functional impairment were recorded.The excised lumbar facet joints were collected as species.The content of interleukin-1? and tumor necrosis factor-? in the species were determined by ELISA.[Results]There was no TNF-? detected in both of the two groups.More IL-1? was detected in degenerative lumbar spinal canal stenosis group than that in lumbar intervertebral disc herniation group.It was demonstrated that the content of IL-1? in the species increased as the degeneration of lumbar facet joint sharpened.IL-1?-positive cases in degenerative lumbar spinal canal stenosis group showed higher grading of backleg pain,melosalgia and functional impairment.[Conclusion]The cartilage of degenerative lumbar spinal canal produced more IL-1?.Lumbar facet joint derived inflammatory factors might be one of the reasons that cause backleg pain and melosalgia and functional impairment in degenerative lumbar spinal canal stenosis patients.
