Effect of salvianoli acid B and hyperoxic solution on experimental ischemia reperfusion injury of extremities
- VernacularTitle:丹酚酸B联合高氧液对兔肢体再灌注损伤保护作用
- Author:
Hanwen LUO
;
Zhiwei CHEN
;
Yiqun LI
- Publication Type:Journal Article
- Keywords:
hyperoxic solution;
salvianoli acid B;
ischemia reperfusion injury
- From:
Orthopedic Journal of China
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effect of salvianoli acid B and hyperoxic solution on experimental ischemia reperfusion injury of extremities.[Method]Twenty-four healthy New Zealand rabbits were divided into 4 groups randomly.Equivalent 0.9%Nacl(group A),hyperoxic solution(group B),salvianoli acid B(group C),salvianoli acid B and hyperoxic solution(group D) were injected through ear edge vein before ischemia.The femoral artery and vein were blocked and the model of ischemia reperfusion injury of extremities was set up.Before ischemia and after 4 hour's reperfusion,the blood samples were taken to measure the levels of blood malondialdehyde(MDA) and superoxide dismutase(SOD).The gastrocnemius muscles were observed by pathologic test.[Result]Serum enzymatic activity of MDA improved obviously.Salvianoli acid B and hyperoxic solution could prevent the improvement of it(P
