AN EXPERIMENTAL STUDY OF INFLUENCE OF INTERRUPTING HEPATIC BLOOD FLOW TO THE LIVER
- VernacularTitle:肝血流阻断对肝脏影响的实验研究
- Author:
Zhenxing TU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1983;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
It has been concerned by the people for a long time to unfold the interruption of hepatic blood flow in security. The present work was undertaken for the clinical practice. 59 heathy adult rabbits were used in this study. These animals were divided into three groups; (1) ligating the right branch of the hepatic artery, (2) ligating tne right branch of the portal vein, and (3) ligating both the right branch of the hepatic artery and portal vein. The hepatic weight, histology, ultrastructure and serum enzymes were observed at regular intervals after the operation. Vaso-graphys were also performed in the selected animals to investigate reconstruction of collateral vessels.The experiment results;1. During the earlier stage after the ligation of the right hepatic artery, in-farct areas of various extent were occurred in the lobe from which the arterial blood supply had been excluded. Finally, they can be classified into two types, the restored type (55.6%) and the infarction type (44.4%). After the ligation of the right portal vein, the ligated lobes became atrophic, and nonligated lobes became compensatory hepertrophic, and by a balance of the two processes the original weight of the liver was maintained. After the ligation of both the right branch of the hepatic artery and portal vein, the infarction was total in lobes supplied by the occluded vessels in 83 per cent of animals. There were partial normal liver tissues remained only in three rabbits.2.On the third postoperative day, the serum GPT activity rose much higher in the animals of 3 rd group than that in the 1 st or 2 nd group.3.The collateral circulation was reconstructed at the 25 th day after ligating the right hepatic artery, while there was no collateral circulation reconstructed after ligating the right portal vein.4.The rabbits could tolerate about 20 per cent of acute infarction of liver tissues.The authors are conveined that;1.There were some dangerous after the ligation of the hepatic artery. The extent of hepatic infarction may be reduced after interrupting the hepatic arterial flow if we could take some methods to alter the stagnation of portal blood flow and to enhance the hepatic cell against hypoxymia.2.The ligation of the branch of the portal vein may be practiced in the clinic. There was no bad result to the organism.3.The ligation of both the branch of the hepatic artery and portal vein should not be performed, and this may lead to severe consequence.4.In the early period after operation dynamic observating the serum GPT activity may be used to evaluate the degree of the liver damage.
