Expression of nephrin,TGF-?1 and WT1 in adriamycin-induced-nephropathy rat model and its significance
- VernacularTitle:Nephrin、TGF-?1和WT1在阿霉素肾病模型肾小球中的表达及意义
- Author:
Weina YANG
;
Shuting REN
;
Shaoli CHENG
;
Yaojie ZHANG
;
Linhua YU
;
Shangwen GUO
;
Hengli LI
- Publication Type:Journal Article
- Keywords:
adriamycin nephropathy;
nephrin;
transforming growth factor-?1;
podocyte
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate podocyte number,the expression of nephrin and transforming growth factor-?1(TGF-?1) in adriamycin-induced-nephropathy rat model and its significance.Methods The rat adriamycin nephrosis model was constructed to detect blood and urine biochemical indicators and observe the pathological changes of renal tissues by light microscope and electron microscope.The expression levels of nephrin and TGF-?1 as well as the podocyte number were examined at different time points by immunohistochemistry.Results The pathological changes of the renal tissues were obvious.Nephrin presented a weak signal at the end of the first week(P
