AN EXPERIMENTAL STUDY OF MESENTERIC MICROCIRCURATION OF BURNED RAT
- VernacularTitle:大鼠烧伤后肠系膜微循环的观察
- Author:
Yulin CHEN
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1983;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
The early changes in microcirculation of burns are of significant pathophsi-ologic importance. The experimental use of cimetidine, an antagonist of histamine H2-receptor, demonstrated its better effectiveness against the changes in microva-scular permeability. No observations on blood flowing state were made. The post-burn adherence of White blood cells to venules were noted recently by Eriksson, which was considered as a pathophysiologic mechanism of postburn tissue edema.A 20% body surface area third degree burn is produced in rats, which is designed an experimental model for observation of the changes in mesenteric microcirculation and a comparative relationship between the adherence of white blood cells and the tissue water content, a comparative therapeutic effect of early resuscitation with Ringer's lactate solution and the results of blood flow in microcirculation, adherence of white blood cells, and aggregation of red blood cells obtained by administration of cimtldine.The chief findings of mesentery microcirculation of burned rat are venule dilatation with progressive slowing and sludging of blood flow; preipheral rotation and adherence of white blood cells; progressive aggregation of red blood cells. No edema is found by measuring water content of remote tissue, better therapeutic effects are shown both by resuscitation of fluid and administration of cimetidine, with the former in predeminanee. The present study indicates:1.Hypovolemia caused by postburn fluid loss and venule dilatation is a major factor leading to worsening of microcircuration blood flow. In order to maintain normal flow state, to assure abetter tissue perfusion, the administration of cimetidine associated with fluid resuscitation may be beneficial.2.Low flow state of microcirculation is the underlying cause, but not the only one of adherence of white blood cells postburn.3.Adherence of white blood cells within venules does not lead to tissue edema, it is, therefore, not the cause of remote tissue edema. The point of view of Eriksson merites further discussion.4.The problems of aggregation of red blood cells and remote unburned tissue edema are also discussed in the present artical. The primary danger of aggregation of red blood cells is to make worsen of the microcirculation, which aggravates the deficiency of blood and oxygen; timely correction of hypovolumia is a preventive measure of primary importance. The experimental model revealed that if no fluid is administered, some, then shows slightly mild dehydration. This might probably be due to the compensatory responce of the remote area to hemoconcen-tration.
