Effect of Bisphenol A on the Structure of Spleen and the Expression of ER-? in Rats
- VernacularTitle:双酚A暴露对大鼠脾脏结构及雌激素受体-?表达的影响
- Author:
Song MIAO
;
Zengqiang KOU
;
Zhixian GAO
- Publication Type:Journal Article
- Keywords:
Bisphenol A;
Receptors,estrogen;
Spleen;
Rats
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of bisphenol A on the structure of the spleen and the expression of ER-? in F344 rats. Methods Fisher 344 rats were randomly divided into control,low-dose,moderate-dose and high-dose groups,10 in each and treated with bisphenol A through gavage at the doses of 4 mg/kg,40 mg/kg and 400 mg/kg respectively,once a day for 17 consecutive weeks. In the end of the experiment,the pathological examination of the spleen was done and the expression of ER-? was detected by western blotting. Results Compared with the control,the weight of high dose group decreased (P
