Advances in Researches on Metabolic Mechanism and Toxicity of Phthalate Esters
- VernacularTitle:邻苯二甲酸酯类化合物的体内代谢及毒性研究进展
- Author:
Yahui ZHAO
;
Xiaoyi WANG
;
Xingtao LIN
- Publication Type:Journal Article
- Keywords:
Phthalate esters;
Phthalate mono-esters;
Metabolic mechanism;
Toxicity
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Phthalate esters widely exist in the environment. It has been demonstrated that they are harmful to human bodies. Phthalate mono-esters are the first metabolite of phthalate esters. In general,biotransformation or metabolism of xenobiotics most frequently result in detoxification of the chemical and facilitates excretion from the body. However,this may not be the case for phthalates. In the present paper,metabolism of phthalate esters and the toxicity of the phthalate mono-esters were reviewed,not only the effect of their mutagenesis,teratogenesis and carcinogenesis,but also their toxicity on reproduction,development,hormones,nuclear receptor,inflammation and obesity were included.
