Effects of Aluminum on cAMP/Protein Kinase A Approach Related to Learning and Memory
- VernacularTitle:铝作用于cAMP-蛋白激酶A途径及对学习记忆的影响
- Author:
Jiajun SUN
;
Wei XING
- Publication Type:Journal Article
- Keywords:
Aluminum;
Cyclic adenosine monophosphate;
Protein kinase A;
Learning and memory
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aluminum is a common metal element,and its nervous toxicity probably has an effect on the learning and memory mechanism. Long-term potentiation (LTP) is an available electrophysiology-model,cAMP/protein kinase A (PKA) approach is an important signal transduction pathway of nerve cells,and plays an important role in the process of learning and memory mechanism. Aluminum has some adverse effects on learning and memory through influencing some links,such as neurotransmitter,Ca2 + concentration,protein kinase and so on. According to the recent studies in this field,in electrophysiology and biochemistry,the present paper reviewed the effects of aluminum on the learning and memory mechanism,as well as the role of cAMP/PKA approach.
