Correlation between FOXO3A Gene Polymorphisms and Human Longevity in Bama County,Guangxi Province
- VernacularTitle:FOXO3A基因多态性与广西巴马县长寿现象的相关性研究
- Author:
Xiangjuan LI
;
Zhiyong ZHANG
;
Jian QIN
- Publication Type:Journal Article
- Keywords:
FOXO3A gene;
Bama Area;
Longevity
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between 8 single nucleotide polymorphisms(SNPs) of FOXO3A gene and human longevity in Bama county.Methods Genotyping of FOXO3A gene was performed by TaqMan-PCR technique for 177 longevous peolpe(aged 90-110) from Bama longevity area and 148 healthy controls(aged 48-89) from Bama non-longevity area.Results Minor allele frequencies of 5 known FOXO3A SNPs(rs2764264,rs9400239,rs13217795,rs2802288 and rs2802292)in cases were significantly higher than those in controls(P5%).Frequency of haplotype 'AG'in cases was significantly higher than that in controls,and frequency of haplotype 'TTTGTC'in cases was significantly lower than that in controls(P
