A Simple Method for Determination of Serum Fibronectin Activity and Its Clinical Application
- VernacularTitle:血清纤维结合蛋白的测定并初步试用于临床病例的观察
- Author:
Wenhua HUANG
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Fibronectin(FN), a blood glycoprotein with non- specific opsonic activity, plays an important role in the process of phagocytosis of macrophages and in the clearance function of reticuloendothelial system(RES) as well. Its level in the circulating blood usually declines in case there is trauma, burn, shock, sepsis or many other diseases probably due to excessive consumption. Then dysfunction of RES and suppression of the body defence mechanism are thus resulted.This paper is to report a simple method to determine the binding activity between gelatin and FN with indirect agglutination assay. Altogether 123 patients suffering from burns, acute peritoneal infections, operative trauma and certain liver diseases were studied. It was found that the serum FN level was closely related with and parallel to the clinical course and severity of the illness. It is suggested that this method for the measurement of serum FN be used as one of the routine assays to reflect the functioning conditions of RES and the defence mechanism of the host.
