EFFECTS AND MECHA NISMS OF HUMAN UMBILICAL-CORLD BLOOD-DERIVED INTERFERON-? AND ASTRAGALUS MEMBRANACEUS ON NATURAL KILLER CYTOTOXICITY
- VernacularTitle:人脐血~?干扰素和黄芪对NK细胞毒影响的研究
- Author:
Jianping JIN
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1983;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
Natural Killer(NK)cytotoxicity of human PML coulcb be markedly increased by human umbilical-corld-blood-derived interferon-? (P-IFN) and Astragalus membranacesu (AIMember.)but slightly inhibited by high concentration of P-IFN (105u/ml) or A-Membr. (10mg/ml) .P-IFN and A.Membr., on the other hand, could protect target cells from NK cytotoxicity.However, this effect was lower than that of their enhancement of NK cytotoxicity.Moreover, P-IFN and A.Membr .could enhance each other.NK cytotoxicity might be increased by 5 to 6 times when the both agents were com-bined ia treatment of effector cells. A.Membr could induce interferon-r which mediated the enhancing effect of A.Membr NK cytotoxicity.There was a relationship be-tween enhancing effect of P-IFN on NK activity and large molecular metabolism of effector cells. It was supposed that interferon, except for activating NK cytotoxicity directly, might stimulate lymphocytes producing other kinds of factors by which interferon might further amplify its enhancing effect on NK cytotxicity.
