EXPERIMENTAL STUDY OF FEMORAL VASCULAR ANASTOMOSIS IN RATS WITH ACUTE RADIATION SICKNESS
- VernacularTitle:急性放射病的大鼠股血管吻合实验研究
- Author:
Xionghua GU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1983;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
Although microsurgical technuiqes have been widely applied to clinical treatments yet it remains unknown whether small vessels can be anastomosed in acute radiation sickness.TO search for clues to the above-mentioned problem, experiments of femoral vas-cular anastomosis were performed on 100 white Wistar male rats ranging from 250-310 g. in weight, 80 of which were equally divided into four groups, i. e. A, B, C, and E.Cobalt 60r-rays were used to exercise one-time irradiation on the whole body at a dose of 500 rad.Right femoral vessels were trans-versely cut off and immediately anastomosed in various stages following radiation. Another twenty rats (Control GrouP D) were used as controls which took femoral vascular anastomosis without being irradiated. one rat died preoperatively of acute radiation sickness on the very day of the operation, reducing the number to 99 femoral ateries and 99 femoral veins anastomosed The effect of Rhizoma Lingustici Wallichii (R. L. W. )on raising the patency rate of small vessels following microvascular anastomosis during acute radiation sickness was observed.All the experimental animals were killed postoperatively on the 3rd-5th. day, 8th -11th.day,21st day, 30th.day and 60th.day respectively, and the specimens collected end obsreved both with the naked eye and under microscopes.we found that the immediate patency rate of the anastonoscd vessels was 100%; 77 out of 79 ateries (97.4%) and 60 out of 79 veins (76.%) renained patent on the 3rd.to 60th.days after feioral vascular anastomosis in the irradiated goups.In the control group the patency rate of arteries and veins were unchanged (20/20). Histological examinations showed that endothelial cells were swelling in degeneration and lost,hyaline degeneration and necrosis in the media were more severe, while the hyperplasia of endothelial cells were slower in the .irradiated groups than in the control Group.The possibility of microvascular anastomosis, choosing the right moment for operation, and the pathological Change of the vessels etc. in acute radiation sickness were discussed. The results observed after the application of R. L. W. were also discussed.The results showed that microvascular anastomosis of small vessels is feasible in mild or less moderate radiation sickness, suggesting that the ideal moment for openation should be the recovery phase of acute radiation sickness.In this study, it was found that the effect of R.L. W. improving patency rate of microvascular anastomosis in acute radiation sickness was not significant.
