Establishing and evaluating of mouse closed femur fracture
- VernacularTitle:小鼠闭合性股骨骨折模型的建立与评估
- Author:
Lianfang ZHANG
;
Jin QI
;
Jinshen WANG
- Publication Type:Journal Article
- Keywords:
mouse;
fracture device;
femur closed fracture
- From:
Orthopedic Journal of China
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To develop a standard closed experimental fracture model in mouse femur.[Method]A 0.45 mm stainless-steel rod was introduced into the medullary cavity and the pre-nailed femur shaft was fractured by an impact device,which resulted in a reproducible transverse fracture pattern.The fractures were examined using X-ray Micro-CT,and histological method.[Result]Transverse fractures were created in 91.67% of the experimental mice,and the fracture healing was typical secondary fracture healing.[Conclusion]The standard closed fracture model in this experiment,whose healing was typically secondary fracture healing,can be obtained easily and used in study of fracture.
