Study on the correlation between hepatitis B virus infection in mother and immune effect of hepatitis B vaccine in infant
- VernacularTitle:母亲乙型肝炎病毒携带状况与新生儿乙肝疫苗免疫效果关系的探讨
- Author:
Ruifang LI
;
Jian DENG
;
Lianshan ZHANG
;
Yanxia MA
;
Nana GUO
;
Ruiling GUO
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Genotype;
Hepatitis B vaccines;
Disease transmission,vertical
- From:Chinese Journal of Disease Control & Prevention
2009;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the correlation between hepatitis B virus infection in mother and immune effect of hepatitis B vaccine in infant so as to explore ways to prevent mother-to-infant transmission.Methods 8 022 aged from 7 months to 2 years old children and their mothers were selected.The children's HepB immunization were investigated.The serological investigation of mother and children were tested by the colloidal gold tripes and ELISA methods.The HBV genotype were detected among HBsAg positive mother.Results The mother's carry rate of HBsAg was 2.43% while the children's was 0.45%.The protect rate of HepB was 81.48%.127 genotype C were detected among 146 HBsAg positive mothers.There were 26 pair of mothers and their children whose's HBsAg were both positive.Nine of the mother's HBeAg and HBcAb were positive.While five of the mother's HBeAb and HBcAb were positive,and ten of the mother's HBcAb were positive.The differences of the three were statistically significant (?2=6.03,P
