TUMOUR CHEMOTHERAPY SYNTHESIS AND ANTITUMORN ACTIVITY OF 1-(N-BENZOYL)AND 1-(N-BENZENE- SULFONYL) AMINO ACID-3, 3-DIMETHYLTRIAZENE DERIVATIVES
- VernacularTitle:1-(N-苯甲酰)和1-(N-苯磺酰)氨基酸-3,3-二甲基三氮烯的合成及其抗肿瘤活性
- Author:
Jianben SHAO
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1983;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
Seven 1-(N-benzoyl) and eight 1-(N-benzenesulfonyl) amino acid-3,3-dimethyli triazene derivatives were synthesized in order to search for antitumor agents with lower toxicity.These compounds were tested for growth inhibitory activity in a micro-bial antitumor screen and for their antitumor activity against the L615 leukemia in mice.The screening data showed that the antitumor activity in the L615 leukemia screen was almost identical with that of growth inhibitory for Lactobacillus casei var.The most active compounds in this study were compounds 2 and 3 which were more potent than 1-(p-Carboxy phenyl)-3, 3-dimethyltriazene and showed lower toxicity.The ILS values for compounds 2 and 3 were 400% and 336.1% respectively and LD50 values were over 2000mg/kg (ip) in mice.
