Expressions and Clinical Significance of PTEN,Fas/FasL and MMP-2 in Gastric Cancer
- VernacularTitle:PTEN、Fas/FasL和MMP-2在胃癌组织的表达及其临床意义
- Author:
Peng WANG
;
Lin GUO
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Phosphatase and tensin homolog deleted on chromosome ten;
Fas/FasL system;
Matrix metalloproteinases-2;
Gastric cancer;
Immunohistochemistry
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of phosphatese and tensin homolog deletedin chromosom ten (PTEN),Fas/FasL system and matrix metalloproteinnases-2 (MMP-2) in human gastric cancer.Methods Seventy-five cases of gastric carcinoma were selected from paraffin wax embodied specimens with full clinicopathological data,and another 15 cases of normal gastric mucosa specimens were selected as the control group.SP immunohistochemistry was used to measure the expressions of PTEN,Fas/FasL and MMP-2 in them.The data was statistically analyzed by ?2 test and relative analysis.Results The expressions of PTEN,Fas/FasL and MMP-2 were correlated with the lymphatic metastasis,degree of infiltration,clinical TMN stage and pathological histological differentiated degree of gastric cancer (P
