Effect of Intensive Insulin Therapy on Inflammatory Level of Biliary Pyemia
- VernacularTitle:强化胰岛素治疗对胆源性脓毒症炎症反应水平的影响
- Author:
Changchun PU
;
Xigui ZHOU
;
Jieliang HU
;
Faping LI
- Publication Type:Journal Article
- Keywords:
Intensive insulin;
Biliary pyemia;
Cytokine;
C-reactive protein;
APACHE Ⅱ score
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible anti-inflammatory mechanism of intensive insulin therapy (IIT) by studying the effect of IIT on the levels of TNF-?,IL-6,C-reactive protein (CRP) and APACHE Ⅱ score in biliary pyemia.Methods Twenty eight patients with biliary pyemia who were admitted by our department and given an operation within 24 h form Jan.2005 to Dec.2008 were randomly divided into two groups by using random number table numbers:one group treated with IIT (IIT group,n=14) and another group treated with routine insulin therapy (RIT group,n=14).The inflammatory factors,such as TNF-?,IL-6 and CRP were detected dynamically and the APACHEⅡ score was calculated.Results The level of CRP and APACHEⅡ score on day 5 and 7 and the levels of TNF-? and IL-6 on day 3,5 and 7 after operation in IIT group were significantly lower than those in RIT group (P
