Relationship Between Vascular Dementia and Plasma Homocysteine Level
- VernacularTitle:血浆同型半胱氨酸水平与血管性痴呆的关系
- Author:
Deliang CAI
;
Zhongxing ZHANG
;
Zaohuo CHENG
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
Homocysteine;
Folate;
Vitamin B12
- From:Chinese Journal of Clinical Psychology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between plasma homocysteine (Hcy),serum folate,Vitamin B12 levels and Vascular dementia (VD).Methods:30 VD patients,58 patients with nondemented cerebral infarction and 30 normal subjects of the same age were recruited in to the study.Their plasma Hcy levels were measured by reversed phase high performance liquid chromatography (RP-HPLC),and the levels of serum folate and Vitamin B12 were also determined by radioimmune assay (RIA).Results:Mean of Plasma homocysteine concentrations were significantly higher in VD group than in the nondemented cerebral infarction group.Which were significantly higher in the nondemented cerebral infarction group than in the normal subjects of the same age.Serum folate levels in the VD group were significantly lower than those in the nondemented cerebral infarction group.Which were significantly lower than those of normal subjects.Conclusion:Hcy may be a new risk factor for the onset of VD.
