Relationship among mTOR and HIF-1? expression and angiogenesis in gastric cancer
- VernacularTitle:胃癌组织中mTOR和HIF-1?的表达及血管生成
- Author:
Lijuan FENG
;
Xuefeng LU
;
Qingsi HE
;
Qinyi WANG
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma?mTOR?HIF-1??MVD
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To detect the expressions of mTOR and HIF-1?and their relationship with angiogenesis in gastric carcinomas. Methods: The expressions of mTOR and HIF-1?in gastric carcinomas tissues(n=70)and normal tissues(n=45)were measured by immunohistochemistry staining.CD34 immunostaining was used to measure the microvascular density(MVD).Results: The rates of the mTOR and HIF-1? positive expression were 51.4% and 67.1% respectively. MVD value of gastric cancer tissues was much higher than that of normal tissues(t=4.358, P
