Histocompatibility evaluation of nano hydroxyapatite-40% zirconia composite bioceramic
- VernacularTitle:纳米羟基磷灰石-40%二氧化锆生物陶瓷材料组织相容性评价
- Author:
Chao LI
;
Shuqing TAO
;
Changlin ZHOU
- Publication Type:Journal Article
- Keywords:
hydroxyapatite;
zirconia;
histocompatibility
- From:
Orthopedic Journal of China
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To evaluate the histocompatibility of nano hydroxyapatite-zirconia composite bioceramic.[Methods]According to the standard of ISO 10993-1,cytotoxicity experiment,acute toxicity test,hemolysis test and in vivo implantation(90 days)test were conducted to evaluate the histocompatibility of nano hydroxyapatite-zirconia composite bioceramic.[Results]The score of cytotoxicity experiment was lower than grade I,and there was no significant inhibition of cell growth,no acute toxic reaction or hemolytic reaction.And the in vivo implantation met the requirements of the biological evaluation of implant materials.[Conclusion]Nano hydroxyzpatie-zirconia composite bioceramic showed a good histocompatibility.It has a broad prospect as a biomaterial scaffold in the bone tissue engineering.
