Oxidative Damage in Heart and Lung Tissue Induced by Sulfur Dioxide Exposure of Different Levels in Exercised Rats
- VernacularTitle:不同浓度SO_2吸入染毒诱导运动大鼠心肺组织的氧化损伤效应
- Author:
Xiaoli LIU
;
Fei SHEN
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Air pollution;
Sulfur dioxide;
Exercised rats;
Heart and lung tissue;
Oxidative damage
- From:
Journal of Environment and Health
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of sulfur dioxide(SO2) pollution in different concentrations on activity of SOD,levels of GSH and MDA in heart and lung tissue of exercised rats,in order to elucidate the toxicological mechanism of SO2 pollution.Methods Forty-eight SD rats were randomly divided into eight groups:a rest group(RG),an exercise group(EG),a low pollution exercise group(LEG),a low pollution rest group(LRG),a moderate pollution exercise group(MEG),a moderate pollution rest group(MRG),a high pollution exercise group(HEG) and a high pollution rest group(HRG).All groups,except RG and EG,were exposed to SO2 with different concentrations(5 mg/m3,10 mg/m3,15 mg/m3),meanwhile exercised rats run in a motor-driven wheel at a speed of 8 m/min,2 h/d for 10 days.Rats were sacrificed at 24 h after treatment and the anti-oxidative enzymes activity and lipid peroxidation(LPO) levels were measured.Results Compared with RG,SOD activity of lung tissue significantly decreased in HEG,MEG,LEG(P
