Effects of Taurine-zinc on Blood-brain Barrier Permeability of Rats Exposed to Lead
- VernacularTitle:牛磺酸锌对铅暴露雄性大鼠血脑屏障通透性的影响
- Author:
Wenbo LIU
;
Jinjin ZHANG
;
Lixia ZHANG
- Publication Type:Journal Article
- Keywords:
Metal,heavy;
Lead;
Taurine zinc;
Dimercaptosuccinic acid;
Blood-brain barrier
- From:
Journal of Environment and Health
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of taurine-zinc(TZC) on blood lead content and blood-brain barrier(BBB) permeability of growing rats exposed to lead.Methods Male SD rats aged 3 weeks were randomly divided into four groups(8 in each group):control group,lead exposure group,dimercaptosuccinic acid(DMSA) group and TZC group.The exposure group treated with 0.12% lead acetate(0.2 ml/100 g body weight) by intraperitoneal injection,DMSA group and TZC group were treated with the same dose of lead acetate but were respectively supplemented with 5 mg/ml DMSA(2 ml/100 g body weight) by ig and 0.46 g/L TZC solution through drinking.Three weeks later,blood lead content was measured by atomic absorption spectroscopy(AAS) and changes of BBB permeability were observed using lanthanum nitrate tracer method.Results Compared with the lead exposure group,the blood lead level in TZC group and DMSA group was significantly reduced(P
