Effect of Gestation and Lactation Exposure to Low-dose Tributyltin on Development of Mice Offspring
- VernacularTitle:孕期及哺乳期低剂量三丁基锡暴露对子代小鼠生长发育的影响
- Author:
Chengen WANG
;
Jiliang SI
;
Miao ZHANG
- Publication Type:Journal Article
- Keywords:
Fertility;
Tributyltin;
Gestation;
Lactation;
Reproductive toxicity
- From:
Journal of Environment and Health
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of gestation and lactation exposure to low dose tributyltin(TBT) on development of offspring of Kunming mice.Methods The healthy adult pregnant Kunming mice were randomly divided into 4 groups,6 in each group,they were given doses of TBT(100,10 and 1 ?g/kg) by gavage from days 6 of gestation(GD6)to the end of lactation.The number of pups and the number of male,female of each dams were determined,and the body weight of pups on PNDs 1,3,5,7,14,21 was weighed.The eye opening from PND12 and the testes descent from PND13 and the vagina opening from PND20 were examined.Results Compared with the control group,the gestational body weight gain of dams decreased in 100 ?g/kg group(P
