Advances on novel estrogen receptor GPR30
- VernacularTitle:雌激素受体GPR30研究进展
- Author:
Haojun LUO
;
Guanglun YANG
;
Gang TU
- Publication Type:Journal Article
- Keywords:
receptors,estrogen;
receptor,G-protein-coupled;
neoplasms
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupled receptor 30(GPR30) was a novel estrogen receptor identified as membrane associated receptor in the late 1990s.This new member of estrogen receptors was independent of the classic nuclear estrogen receptor ? and ? due to the low homology and signifi cant difference between them.It was reported that GPR30 localized endoplasmic reticulum predominantly,which was expressed in diverse cancer cells and a wide range of systems throughout the body.The rapid non-genetic response,partially at least,transcription regulation of estrogenic effects were mediated by the novel receptor via transactivation of epidermal growth factor receptor and modulation of second messengers such as cyclic adenosine monophosphate(cAMP) and Ca2+.These pathways,possibly coordinate with ER?,were involved in various physiological,physiopathological and carcinogenesis process.Theoretically,GPR30 would be a novel therapeutic target in estrogen-related diseases such as breast carcinoma.
