Expressions and clinicopathological significance of MCM5 and E2F-1 in patients with gastric carcinoma
- VernacularTitle:MCM5和E2F-1在胃癌组织中的表达及临床病理意义
- Author:
Lei ZHANG
;
Suwen WANG
;
Wei GAO
;
Bin TIAN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Transcription factor E2F-1;
Minichromosome maintenance 5;
Immunohistochemistry
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the expressions of MCM5 and E2F-1 with the genesis,clinicopathological parameters of gastric carcinoma.Methods:Immunohistochemistry SP method was used to detect the expressions of MCM5 and E2F-1 in gastric car- cinoma tissues of 57 cases and in normal gastric mucosa of 20 cases.The correlation between expressions of MCM5 and E2F-1 and clinicopathological parameters of gastric carcinoma was analysed. Results:The positive expression rate of MCM5 in cancer tissues was 71.9%(41/57),while in normal mucosa it was 0(0/20).The difference between the two groups was statistically significant (P0.05).The correlation between MCM5 and E2F-1 expressions in gastric carcinoma was highly significant positive(r=0.635,P=0.000).Conclusion: Overexpression of MCM5 and E2F-1 corelates with occurence and development of gastric carcinoma.MCM5 and E2F-1 may work in the early phase in carcinogenesis of gastric carcinoma.
