Analysis of clinical and pathological features of familial gastric cancer
- VernacularTitle:家族性胃癌临床及病理特征分析
- Author:
Hongxin NIU
;
Zhongfa XU
;
Huiyong SHI
;
Lili WANG
- Publication Type:Journal Article
- Keywords:
Familial gastric cancer;
Clinical features;
Pathological features;
E-cadherin gene;
Germline mutation
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical and pathological features of familial gastric cancer, and to get the early discovery and early treatment of it.Methods:Two kindreds of familial gastric cancer were followed up and their clinical and pathological features were analyzed.Results:Six patients with gastric cancer were found in the 2 kindreds.Autosomal dominant inheritance was observed in these cases.clinical and pathological features of familial gastric cancer were showed according to the document analysis:early onset;poor prognosis;patients suffer simultaneous or metachronous carcinoma;CDH1 germline mutation carriers had higher penetrance;pathologically, tumors are mostly diffuse infiltrative type with lower differentiated degree and earlier metastasis to lymphnodes;in one kindred,the sites of the lesions were relatively consistent.Conclusion:Familial gastric cancer has particular clinical and pathological features:early onset;poor prognosis;patients suffer simultaneous or metachronous carcinoma;CDH1 germline mutation carriers have higher penetrance; pathologically,tumors are mostly diffuse infiltrative type with lower differentiated degree and earlier metastasis to lymphnodes.
