Effect of Ligustrazine on nNOS expression in different encephalic regions after focal cerebral ischemia in adult rats
- VernacularTitle:川芎嗪对脑缺血后不同脑区神经元型NO合酶表达的影响
- Author:
Fen QIU
;
Yong LIU
;
Bo MA
;
Cunfang QI
;
Wenjing WANG
- Publication Type:Journal Article
- Keywords:
Ligustrazine;
cerebral ischemia;
neuron NO synthase;
subventricular zone(SVZ);
corpus callosum(CC);
striatum;
dentate gyrus(DG)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).In SVZ,nNOS expression in ischemic model group was reduced on days 1-14,but increased on day 21;after Ligustrazine administration,nNOS expression was obviously decreased on days 3-14 in all Ligustrazine dose groups,but began to increase on day 21.In CC,nNOS expression in ischemic model group was reduced on days 3-14,and began to increase on day 21;in the different-dose Ligustrazine groups,nNOS expression was significantly decreased on days 3-14,especially in medium-and high-dose groups,but increased on day 21.In striatum and cortex peri-infarction,nNOS expression in ischemic model group was obviously decreased on days 3 and 7,but enhanced on days 14 and 21;in various-dose Ligustrazine groups,nNOS expression was decreased on days 3-21,especially in medium-and high-dose groups,but increased slightly on day 21.In DG and CA1 areas,nNOS expression in ischemic model group was reduced on days 3 and 7,but began to increase on day 14;nNOS expression in all Ligustrazine groups were decreased during 3-21d.There were significant differences between ischemic model group and different-dose Ligustrazine groups at different time points(P
