Effect of Nbn gene on hippocampus development in postnatal mice
- VernacularTitle:Nbn基因对出生后小鼠海马发育的影响
- Author:
Kun WANG
;
Rui ZHANG
;
Min GUO
- Publication Type:Journal Article
- Keywords:
Nbn;
mouse;
hippocampus development;
stereology
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of neuro-specific DNA repair gene Nbn in mouse hippocampus development by observing the morphological differences in Nbn-CNS-Del and Nbn-CNS-Ctr mice.Methods Serial sections and stereology were used to quantitatively analyze the development of mouse hippocampus on postnatal day 7,14 and 21.Results Compared with that of the control group,the hippocampus development of Nbn-CNS-Del mice lagged behind.In Nbn-CNS-Del mice,on day 21,the profile area of pyramidal layer of hippocampus and granular layer of dentate gyrus decreased(P
