CLINICAL RELATIONSHIP BETWEEN ALPHA-FETOPROTEIN VARIANTAND HEPATOCELLULAR CARCINOMA
- VernacularTitle:甲胎蛋白异质体和原发性肝癌的临床联系
- Author:
Zhenxing TU
- Publication Type:Journal Article
- Keywords:
hepatoma;
AFP;
variant
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, alpha-fetoprotein variant (AFP variant) in serum and tumor tissue from patients with hepatocellular carcinoma (HCC) was determined by lectin crossed-immuno-affino-clectrophoresis (LCIAE). The cirrhosis and liver diseases without tumor were taken as control.The results indicate that two kinds of AFP variants were found by LCIAE method and they were different in the HCC patients from different areas,The ratios of two kinds of AFP variants in serum and tumor tissue were near, indicating there are tumor cells in liver, which can secrete two kinds of AFP variants.AFP-N-L content is closely related with tumor size, tumor cell differentiation, histological behaviors, tumor capsulc, tumor thrombus, etc.Tumor cells with high malignance secrete mainly LCA-R-AFP.
