Significance of AKT2 and PTEN protein expressions and their correlation with human colon cancer
- VernacularTitle:人结肠癌中AKT2和PTEN蛋白表达的意义及相关性
- Author:
Hongbo ZHAO
;
Xiaoyuan ZHANG
;
Di LIU
;
Yongjie LIU
;
Pu ZHANG
- Publication Type:Journal Article
- Keywords:
colon cancer;
PTEN;
AKT2;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of AKT2 in human colon cancer and understand its relationship with PTEN.Methods The expressions of AKT2 and PTEN were detected in 30 patients with normal colonic tissues,30 patients with colon adenoma tissues,and 64 patients with colon carcinoma tissues by immunohistochemical SP staining method.Results The positive expressive rate of PTEN presented a trend of progressive decrease from normal tissues,adenoma tissues to colon carcinoma tissues,while the positive expression rate of AKT2 presented a trend of progressive increase.PTEN expression was obviously higher in normal colon tissues than in colon adenoma tissues and colon cancer tissues(?2=68.855,P
