Microvascular density,DNA ploidy and immunophenotype in prostatic intraepithelial neoplasia as well as their relationship with its biological properties
- VernacularTitle:前列腺上皮内瘤中微血管密度、DNA倍体、免疫表型与其生物学特性的关系
- Author:
Huilian HOU
;
Xuebin ZHANG
;
Xu LI
;
Guanjun ZHANG
;
Hongyan WANG
;
Yuan DENG
;
Min WANG
- Publication Type:Journal Article
- Keywords:
prostatic intraepithelial neoplsia(PIN);
prostatic carcinoma(PC);
microvascular density(MVD);
DNA ploidy;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study microvascular density(MVD),DNA ploidy and immunophenotype in prostatic intraepithelial neoplasia(PIN) as well as their relationship with its biological properties.Methods We studied paraffin-embedded specimens from 24 cases of benign prostatic hyperplasia(BPH),23 cases of low-grade prostatic intraepithelial neoplasia(LGPIN),and 26 cases of prostatic carcinoma(PC) with high-grade prostatic intraepithelial neoplasia(HGPIN).Image analysis was used to measure the DNA average ploidy and MVD,and after that the expressions of 34?El2,P63,P504s and CD34 were detected by immunohistochemistry SP.Results DNA ploidy and MVD in PIN were higher than those in BPH,but lower than in PC,and correlation was detected among different grades of PIN.MVD had a positive correlation with DNA aneuploidy in different grades of PIN(P
