Inhibition of curcumin on proliferation of human osteosarcoma U-2OS cells
- VernacularTitle:姜黄素对人骨肉瘤U-2OS细胞增殖的抑制作用
- Author:
Yang XIAO
;
Wanchun WANG
- Publication Type:Journal Article
- Keywords:
curcumin;
osteosarcoma cells;
proliferation
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the inhibition of different concentrations of curcumin on cell growth,and explore the molecular mechanism of curcumin on human osteosarcoma.Methods Curcumin of different concentrations(0,10,20 and 40?mol/L) was administered to U-2OS cells of human osteosarcoma for 12h,24h and 48h,respectively.The proliferation of U-2OS cells was measured by MTT assay.Results Curcumin significantly inhibited the proliferation of PC-3 cells in vitro in concentration-and time-dependent manners.The higher the concentration of curcumin,the stronger the inhibition was(10?mol/L,20?mol/L,40?mol/L of r=-0.9638,-0.9778 and-0.9764,respectively,P
