Common phenotypic molecule for classification of NK cell subsets of both human and mouse:CD27 molecule
- VernacularTitle:人和小鼠NK细胞亚群划分的共同标志的发现:CD27分子
- Author:
Xian WU
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
NK cells;
CD27;
CD11b;
Subsets;
MHC class Ⅰ molecular
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
NK cells can be divided into two subsets based on CD27 expression:CD27hiNK cells and CD27loNK cells.NK cells can be further divided into four subsets based on CD27 and CD11b: CD11bloCD27lo,CD11bloCD27hi,CD11bhiCD27hi and CD11bhiCD27lo.These subsets in different development stages have their own phenotypes and functions.In mice,NK cell developing pathway is through CD11bloCD27lo→CD11bloCD27hi→CD11bhiCD27hi→CD11bhiCD27lo.CD27 can also be used to divide human NK cells into two subsets which are comparable to those of mice.
