Combined Toxic Effects of DBP and DEHP on Spermatogenesis in Male Rats
- VernacularTitle:邻苯二甲酸二丁酯和邻苯二甲酸二(2-乙基己基)酯联合染毒对雄性大鼠精子生成的影响
- Author:
Xiaomei TIAN
;
Ling LI
;
Qiru SONG
- Publication Type:Journal Article
- Keywords:
Fertility;
Di-(n-butyl) phthalate;
Di-(2-ethylhexyl) phthalate;
Combined action;
Spermatogenesis
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).DBP and DEHP obviously induced a decrease in organ body weight ratios of testis and epididymis and an increase in organ body weights ratios of liver.Obvious decrease in the sperm counts,spermatozoon survival rate and significant increase in the rate of the sperm deformation were observed.There was synergism between DBP and DEHP on the testis,epididymis and liver organ body weight ratio,as well as sperm counts,sperm survival and deformation rates.Pathological examination showed the seminiferous tubules were irregular shape,degenerative atrophy and interstitial substance broadening,and the seminiferous epithelium were degeneration.Epididymis epithelium was damaged and few of mature sperm was seen.Conclusion DBP combined with DEHP can cause obvious toxic effects on reproductive function in male rats.DBP and DEHP mixture can strongly affect the sperm quantity and quality.Also,some toxic effects to epididymis are observed.
