Renal Toxicity Induced by Melamine Intake Single and Combined with Cyanuric Acid
- VernacularTitle:三聚氰胺单独及与三聚氰酸联合染毒致大鼠的肾毒性
- Author:
Weijie CHAI
;
Yuyan WANG
;
Minzhi GAO
- Publication Type:Journal Article
- Keywords:
Melamine;
Cyanuric acid;
Renal toxicity
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the renal toxicity induced by melamine intake single and combined with cyanuric acid.Methods Thirty-six clean weanling male Wister rats were randomly divided into 3 groups,12 in each,treated with melamine and cyanuric acid through food for 28 consecutive days,group 1 treated with melamine at 25 mg/kg,group 2 treated with melamine (25 mg/kg) plus cyanuric acid (25 mg/kg),group 3 is control,fed on normal pet food.After 4 weeks of treatment,the rats were sacrificed and blood indicators,histopathological examination of kidney were conducted.Renal tissues from the affected rats were analyzed using high-performance liquid chromatography and mass spectrometry.Kidney X-ray diffraction was performed to determine the existence of crystals.Results In group 1 and 2,polyuria,hypokinesia and weight loss (P
