Research Progress on Mechanism of Neurotoxic Effects Induced by Polybrominated Diphenyl Ethers
- VernacularTitle:多溴联苯醚的神经毒性作用机制研究进展
- Author:
Jin LI
;
Aiguo WANG
- Publication Type:Journal Article
- Keywords:
Environmental pollutants;
Polybrominated diphenyl ethers;
Neurotoxicity
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Polybrominated diphenyl ethers (PBDEs) is a kind of important industrial flame retardants,which widely exists in the environment and biosomes.Some researches have indicated that PBDEs is toxic to the nervous system of animals through affecting the release of neuroendocrine hormone,the signal transduction pathways,the transmission of neurotransmitters,the expression of key proteins in the nervous system,and the apoptosis of neuronal cells.Data from environmental monitoring indicated that environmental exposure to PBDEs in China exists,but the research on the effect of PBDEs on nervous system is very limited,which calls for attention.This article summarized researches on the mechanism of neurotoxic effects induced by polybrominated diphenyl ethers from the aspects such as the release of neuroendocrinal hormone,the signal transduction pathways,the transmission of neurotransmitters,the expression of key proteins in the nervous system,and the apoptosis of neuronal cells,and some ideas about the direction of related researches were presented.
