Platelet Function Changes in Experimental Hemorrhagic Shock
- VernacularTitle:实验性失血性休克时血小板功能的变化
- Author:
Sen HU
- Publication Type:Journal Article
- Keywords:
Hemorrhagic shock;
Platelet functions;
Thromboxane;
Serotonin;
Rabbit
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of hemorrhagic shock on the platelet functions in non-heparinized rabbits were studied. It was found that the platelet adhesiveness and aggregation and the pasma level of serum serotonin and throraboxane B2 significantly increased in the early period of hemorrhagic shock. Thereafter, as the shock was progressing, the platelet adhesiveness and aggregation were gradually inhibited while plasma level of serotonin and thromboxane B2 increased further and reached the peak in the 3rd hour after the onset of shock.The results indicated that the release of vasoactive substances such as serotonin and thromboxane after the activation of platelets seems to play a more important role than platelet adhesion and aggregation in the pathogenesis of hemorrhagic shock.
