Effects of glutamine enriched parenteral nutrition on mucosal ischemia and reperfusion injury of small bowel in rats
- VernacularTitle:谷氨酰胺强化肠外营养对大鼠小肠黏膜缺血再灌注损伤的影响
- Author:
Lipan PENG
;
Leping LI
;
Changqing JING
- Publication Type:Journal Article
- Keywords:
Parenteral nutrition?Glutamine?Reperfusion injury?Intestine?Rats,Wistar
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Small bowel IRI models in rats were established to explore the effect of glutamine enriched parenteral nutrition on mucosal barrier,and to discuss the probable mechanisms.Methods:Thirty Wistar rats were randomly assigned into 3 groups:The control group(N group,n=10) ,conducted fictitious operation and fed with common forage,TPN group(n=10) and TPN+Glu group(n=10) .The morphous of mucous,serum and intestinal mucosal Gln concentration,levels of D-lactate,endotoxin,TNF-?,IL-6,HO-1 positive ratio and HO-1 mRNA were detected.Results:Glutamine obviously improved the structure of intestinal mucosal and decreased the expressions of D-lactate,endotoxin,TNF-?and IL-6.And enhanced the expressions of HO-1 mRNA and HO-1.Conclusion:Glutamine enriched parenteral nutrition can alleviate small intestinal IRI and inflammatory reaction and enhance the HO-1 and HO-1 mRNA expressions.HO-1 and its metabolin's anti-oxygen,anti-apoptosis,anti-inflammator action may be the mechanism of the protective action of Gln on mucosal barrier of small bowel.
