Relationship of expressions of E-cadherin and ?-catenin proteins and gastric mucosa intestinal metaplasia and gastric carcinoma
- VernacularTitle:E-cadherin和?-catenin蛋白的表达与胃黏膜肠上皮化生及胃癌的关系
- Author:
Yao ZHENG
;
Jianping ZHANG
;
Fengjun LIU
;
Jingyan YANG
- Publication Type:Journal Article
- Keywords:
Intestinal metaplasia?Stomach neoplasms?Cadherins??-catenin
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship of expressions of E-cadherin and ?-catenin proteins and gastric mucosa intestinal metaplasia and gastric carcinoma.Methods:The immunohistochemical Envision method was used to determine the expressions of E-cadherin and ?-catenin in 30 cases of simple intestinal metaplasia(SIM) ,38 cases of atypia intestinal metaplasia(AIM) and 55 cases of gastric carcinoma.Results:The reduced expression rates of E-cadherin and ?-catenin in gastric carcinoma were significantly higher than that in SIM(P0.05) .Conclusion :E-cadherin and ?-catenin proteins take part in the transformation from intestinal metaplasia to carcinoma in gastric mucosa,AIM is a kind of precancerosis of gastric carcinoma.
