Differentiation of bone marrow mesenchymal stem cells into nucleus pulposus cells
- VernacularTitle:骨髓间充质干细胞向髓核细胞的转化
- Author:
Chenglong HAN
;
Chao JIANG
- Publication Type:Journal Article
- Keywords:
bone marrow mesenchymal stem cells;
intervertebral disc degeneration;
gene therapy;
tissue engineering
- From:
Orthopedic Journal of China
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells(BMSCs) have the ability of multi-directional differentiation.In different environments,it can be induced into various blastodermic layer cells,such as osteoblast,chondrocyte and so on.Intervertebral disc degeneration(IDD) is mainly the change of nucleus pulposus cells and extracellular matrix.Nucleus pulposus cell is a chondrocyte-like cell.With the progress of cell bioengineering and molecular biology,the tissue engineering nucleus pulposus cells can be regenerated by BMSCs combined with cell carrier.It can be implanted into intervertebral disc to prevent and reverse IDD.It will be a new way for treating IDD.
