Advances in the Investigation of Asthma Phenotypes.
10.7581/pard.2012.22.2.129
- Author:
Ji Won KWON
1
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
- Publication Type:Review
- Keywords:
Asthma phenotype;
Endotype;
Cluster analysis
- MeSH:
Asthma;
Bias (Epidemiology);
Biology;
Cluster Analysis;
Cohort Studies;
Humans;
Inflammation;
Molecular Biology;
Phenotype
- From:Pediatric Allergy and Respiratory Disease
2012;22(2):129-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Asthma is a complex and heterogeneous disease, which is comprised of seperate phenotypes sharing common characteristics, such as airway inflammation, bronchial hyperresponsiveness and variable airflow limitation. Traditionally, asthma phenotypes have been described by combinations of clinical characteristics, according to the expert's recommendation, but they are now focusing on the pathobiologic mechanisms often using exploratory statistical methods. Several phenotypes and endotypes have been suggested by biased or unbiased phenotyping approaches. However, more detailed studies are still needed. In the future, more integrated large-scaled consortium of cohorts, including clinical information, genetics, molecular biology, and experiments will promote to understand the pathobiologic mechanisms of asthma phenotypes for the personalized therapy.
