Effects of mesenchymal stem cells transplantation on the brain-derived neurotrophic factor and growth associated protein-43 after the spinal cord injury of rats
- VernacularTitle:骨髓基质干细胞移植对大鼠脊髓损伤后BDNF与GAP-43基因表达的影响
- Author:
Chunsheng ZHI
;
Lin XIE
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
cell transplantation;
growth associated protein-43;
brain-derived neurotrophic factor
- From:
Orthopedic Journal of China
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the effects of mesenchymal stem cells(MSCs) transplantation on the brain-derived neurotrophic factor(BDNF) and growth associated protein-43(GAP-43) after the spinal cord injury(SCI) of rats, and to investigate the mechanism of repairing the SCI by MSCs transplantation. [Method]Seven days after the operation of SCI,the MSCs were transplanted into the injured site. Then GAP-43 and BDNF were tested by RT-PCR. By means of above,the mechanism of repairing the SCI after the cell transplantation was investigated.[Result]Compared with group B, transplantation of MSCs enhanced the expression of BDNF mRNA and GAP-43 mRNA in the spinal cord of group A, improved the neuron regeneration.[Conclusion] The transplantation of MSCs can repair the injuried site and promote the regeneration of axon by enhanced the expression of BDNF mRNA and GAP-43 mRNA. It is one of the mechanism of repairing the SCI by MSCs transplantation.
