Expressions and relationship of suppressor of cytokine signaling1 and c-myc in human hepatocellular carcinoma tissue
- VernacularTitle:SOCS1与c-myc在人肝细胞癌组织中的表达及相互关系
- Author:
Zhongqing PAN
;
Yugang JIANG
;
Nianping CHEN
- Publication Type:Journal Article
- Keywords:
Hepotocellular,carcinoma?Suppressor of cytokine signaling Proteins?Proto-oncogene protein c-myc
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of suppressor of cytokine signaling 1(SOCS1) and cellular myelocytomatosis oncogene(c-myc)in hepatocellular carcinoma(HCC),and to inves-tigate the relation between the expression of SOCS1 and c-myc in HCC.Methods:The expressions of SOCS1 and c-myc protein of 41 HCC tissues and surrounding tissues,as well as the tissues of 11 normal cases,were detected by immunohistochemical(IHC)staining using SP method.The expression of SOCS1 mRNA was detected by RT-PCR.And the clinical and pathological data were analysed.Results:Compared with the para-carcinoma and normal liver tissue,the levels of SOCS1 and SOCS1 mRNA in HCC tissues were significantly lower(P
