Conparision of the effect of Oxycodone and Morphine controlled-release tablets in the treatment of visceral cancer pain
- VernacularTitle:盐酸羟考酮和硫酸吗啡控释片治疗癌性内脏痛的疗效比较
- Author:
Hui YU
;
Lishuang LIANG
;
Jianfeng WANG
;
Xudong LIU
;
Guozhuan ZHANG
- Publication Type:Journal Article
- Keywords:
Pain?Digestive system neoplasms?Analgesis,opioid
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research and compare the therapeutic effect of oxycodone hydrochloride controlled—release tablets and morphine sulfate controlled—release tablets on the visceral cancer pain.Methods:Total of 72 patients with visceral cancer pain were randomly assigned into two groups:OO group was treaded by oxycodone hydrochloride controlled—release tablets,MO Group was given morphine sulfate controlled—release tablets.According to the principle of NCCN(2008),the two groups were titrated by morphine,and then diverted to controlled-release agent.The visual analogue scale(VAS)was kept smaller than 4.The side effects of two groups'and the rescue analgesic doses were recorded after the application of the controlled-release agent for 15 days,and the cost-effectiveness was analysed.Results:The rescue analgesic doses of the OO group were smaller than that of the MO group (P0.05).Conclusion:The two drugs have notable analgesic effect in the visceral cancer pain.Considered gastrointestinal tract side effects and the rescue analgesic dose,Oxycodone hydrochloride controlled—release tablets surpass the Morphine sulfate controlled-release tablets.Oxycodone hydrochloride controlled-release tablets may be a potential regimen for visceral cancer pain.
