Association between IL-1B+3954/Taq Ⅰ gene polymorphisms and chronic periodontitis
- VernacularTitle:IL-1B+3954/TaqⅠ基因多态性与慢性牙周炎易感性的关系
- Author:
Bing HAN
;
Jianzhong GOU
;
Xi CHEN
;
Shengbin LI
- Publication Type:Journal Article
- Keywords:
periodontitis;
interleukin-1;
single nucleotide polymorphism;
genotype;
susceptibility
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether specific IL-1B+3954/Taq Ⅰ genotype alleles are associated with chronic periodontitis (CP) in Chinese of the Han nationality. Methods CP group consisted of 66 patients while healthy controls group consisted of 50 subjects. Anti-coagulated peripheral blood sample was obtained from each subject and genomic DNA was extracted from each sample. Single nucleotide polymorphisms (SNPs) at IL-1B+3954/Taq Ⅰ were analyzed by standard polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) assay. Results In the control group,higher numerical values of the A1/A1 genotype were observed for the IL-1B+3954/Taq Ⅰ SNPs (84.0%),and the A2+ genotype was present in 16% of this sample. Statistical analysis revealed no significant difference between the two groups. Conlusion There is no evidence in our study supporting the association between single nucleotide polymorphisms (SNPs) of the IL-1B+3954/Taq Ⅰ gene and prevalence and/or severity of chronic periodontitis.
