Effect of intracerebroventricular injection of glutamic acid/MK-801/ketamine on morphine withdrawal syndrome in rats
- VernacularTitle:侧脑室注射谷氨酸、MK-801及氯氨酮对大鼠吗啡戒断症状的影响
- Author:
Hongwei WANG
;
Junbao YAN
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
glutamic acid;
MK-801;
ketamine;
morphine withdrawal syndrome;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between the level of central N-methyl-D-aspartate (NMDA) receptor system and the degree of morphine withdrawal syndrome in rats. Methods We established the morphine-dependence model in rats,stimulated addiction by naloxone after intracerebroventricular injection of glutamic acid/ketamine/MK-801,and then observed the effects on rats' morphine withdrawal syndrome. Results Glutamic acid significantly raised the behavior scores of teeth chattering,wet shakes,writhing,penis licking and weight loss,while ketamine and MK-801 decreased the scores. Conclusion Changes of central NMDA system obviously affect morphine withdrawal syndrome in rats,which may be useful laboratory evidence in selecting new no-opiod therapeutic medicine for morphine resistance and addiction.
