Effect of Chronic Psychological Stress on Learning and Memory in Mice and the Impact of Immune Cells
- VernacularTitle:慢性应激对小鼠学习记忆及免疫细胞的影响
- Author:
Ying MA
;
Li LU
;
Zhaoxia XUE
;
Jie YUAN
- Publication Type:Journal Article
- Keywords:
Chronic psychological stress;
Learning and memory;
Immune cell
- From:Chinese Journal of Clinical Psychology
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of chronic psychological stress on change of function of learning and memory, and CD4, and CD8 in mice. Methods: 50 BALB/c mice were randomly divided into control group and immobilization stress group (n=25 in each group). The mice mode of stress was made by restraint for 6 hours per day. Suspend tail test was performed on change of behaviors in mice. RIA was employed to measure levels of neuropeptide Y in the brain. Results: Compared with the control group, the mean escape latency of the mice in the chronic restraint groups was longer than that of the control mice (P
