Signification and expression of cyclooxygenase-2 in rats with bleomycin-induced pulmonary fibrosis
- VernacularTitle:环氧化酶-2在肺纤维化大鼠中的表达及其意义
- Author:
Junling YANG
;
Zhongmei SUN
;
Qingyan LIN
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase-2;
Pulmonary fibrosis;
Cyclooxygenase inhibitor
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution and expression of the cyclooxygenase-2(COX-2)in lung tissues and the effect of its inhibition in bleomycin(BLM)-induced pulmonary fibrosis in rats.Methods:72 male SD rats were randomly divided into three groups:the control group,model group and celecoxib group.Immunohistochemical method was used to detect the distribution of COX-2 in the stage of acute pulmonary alveolitis.HE and Masson staining methods were used to evaculate the degree of alveolitis and pulmonary fibrosis.Results:(1)In early stage of pulmonary fibrosis except in the control group,COX-2 expression was found in small bronchial epithelial cells in the other two groups,especially the model group.(2)Compared with the control group,the other two groups had alveolitis(P
