Changes of phagotosis function and releas of TNF-? in DM rats alveolar macrophages
- VernacularTitle:糖尿病大鼠肺泡巨噬细胞吞噬功能及释放肿瘤坏死因子?变化的研究
- Author:
Xiujuan LIU
;
Fang ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Alveolar macrophage;
Immune defense
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate functional changes of AMs to explore the mechanisms for weakened pulmonary local immune defense function in DM.Methods:Wistar rat model was established by intraperitoneal injection of streptozotocin at 60 mg/kg.The rats were performed BAL to collected AMs.Cock RBC phagotosis rate of AM was counted with HE method.AMs underwent in vitro incubation,and supernant TNF-? content was determined with ELISA method.Results:The phagotosis rate of 4 weeks DM group and 8 weeks DM group decreased significantly in statistics commpared with the control group(P
