The influence of estrogen on expression of interleukin-6 and nerve growth factor in cardiac ganglia in female rats
- VernacularTitle:雌激素对大鼠心内神经节IL-6和NGF表达的影响
- Author:
Xiaoliu LIU
;
Guangqian LI
- Publication Type:Journal Article
- Keywords:
Interleukin-6;
Nerve growth factor;
Estrogen;
Intrinsic cardiac ganglia;
Immunohistochemistry
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression and variance of interleukin-6(IL-6)and nerve growth factor positive neurons in the intrinsic cardiac ganglia of females that were intact,females that were ovariectomized,or ovariectomized females that were treated with 17?-estradiol.Methods:Immunohistochemical staining technique.Results:IL-6-IR and NGF-IR neurons were presented in the intrinsic cardiac ganglia of these groups,but the number of the IL-6-IR neurons increased remarkably and their expression increased obviously in the intracardiac ganglia of ovariectomized rats,while the number of the NGF-IR neurons decreased remarkably and their expression reduced obviously in the intracardiac ganglia of ovariectomized rats.Conclusion:IL-6 and NGF are present in rat intrinsic cardiac ganglionic cells and they are also influenced by estrogen,suggesting that 17?-estradiol may have the capacity to regulate the expression of IL-6 and NGF in intrinsic cardiac ganglia.
